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3.5: Periods of Prenatal Development

Last updated

Nov 19, 2023
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- 3.4: Genetic and Chromosomal Abnormalities
- 3.6: Teratogens

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Now we turn our attention to prenatal development which is divided into three periods: the germinal period, the embryonic period, and the fetal period. Here is an overview of some of the changes that take place during each period.

The Germinal Period

The germinal period (about 14 days in length) lasts from conception to implantation of the zygote (fertilized egg) in the lining of the uterus. During this time, the organism begins cell division and growth. After the fourth doubling, differentiation of the cells begins to occur as well. It’s estimated that about 60 percent of natural conceptions fail to implant in the uterus. The rate is higher for in vitro conceptions.

magnified photo of sperm approaching ovum. — Figure $\PageIndex{1}$ : Sperm and ovum at conception. (PDM; Unknown via Wikipedia)

The Embryonic Period

The embryonic period begins once the organism is implanted in the uterine wall. It lasts from the third through the eighth week after conception. During this period, cells continue to differentiate and at 22 days after conception the neural tube forms which will become the brain and spinal column. Growth during prenatal development occurs in two major directions: from head to tail (cephalocaudal development) and from the midline outward (proximodistal development). This means that those structures nearest the head develop before those nearest the feet and those structures nearest the torso develop before those away from the center of the body (such as hands and fingers). The head develops in the fourth week and the precursor to the heart begins to pulse. In the early stages of the embryonic period, gills and a tail are apparent. But by the end of this stage, they disappear and the organism takes on a more human appearance.

Embryo at an early stage of development, showing arms and legs and facial features beginning to form. — Figure $\PageIndex{2}$ : During the embryonic period, the head, arms, and legs are clearly visible. (CC BY 2.0; **lunar caustic** via Flickr)

About 20 percent of organisms fail during the embryonic period, usually due to gross chromosomal abnormalities. As in the case of the germinal period, often the mother does not yet know that she is pregnant. It is during this stage that the major structures of the body are taking form making the embryonic period the time when the organism is most vulnerable to the greatest amount of damage if exposed to harmful substances. (We will look at this in the section on teratology below.) Potential mothers are not often aware of the risks they introduce to the developing child during this time. The embryo is approximately 1 inch in length and weighs about 4 grams at the end of this period.

The Fetal Period

From the ninth week until birth, the organism is referred to as a fetus. During this stage, the major structures are continuing to develop. By the 12th week, the fetus has all its body parts including external genitalia. In the following weeks, the fetus will develop hair, nails, teeth and the excretory and digestive systems will continue to develop. At the end of the 12th week, the fetus is about 3 inches long and weighs about 28 grams.

During the 4th-6th months, the eyes become more sensitive to light and hearing develops. Respiratory system continues to develop. Reflexes such as sucking, swallowing and hiccupping develop during the 5th month. Cycles of sleep and wakefulness are present at that time as well. The first chance of survival outside the womb, known as the age of viability is reached at about 22 and 26 weeks (Moore & Persaud, 1998). Many practitioners hesitate to resuscitation before 24 weeks. The majority of the neurons in the brain have developed by 24 weeks although they are still rudimentary and the glial or nurse cells that support neurons continue to grow.

Between the 7th and 9th months the fetus is primarily preparing for birth. It is exercising its muscles, its lungs begin to expand and contract. It is developing fat layers under the skin. The fetus gains about 5 pounds and 7 inches during this last trimester of pregnancy which includes a layer of fat gained during the 8th month. This layer of fat serves as insulation and helps the baby regulate body temperature after birth.

A father kisses a laughing baby. — Figure $\PageIndex{3}$ : Close relationships are the fabric of society, and are integral to the maintenance of our species. (Unsplash License; Mikael Stenberg via Unsplash)

Environmental Risks

Good prenatal care is essential. The developing child is most at risk for some of the most severe problems during the first three months of development. Unfortunately, this is a time at which many mothers are unaware that they are pregnant. Today, we know many of the factors that can jeopardize the health of the developing child. The study of factors that contribute to birth defects is called teratology. Teratogens are factors that can contribute to birth defects which include some maternal diseases, pollutants, drugs and alcohol.

Factors influencing prenatal risks: There are several considerations in determining the type and amount of damage that might result from exposure to a particular teratogen (Berger, 2004). These include:

The timing of the exposure: Structures in the body are vulnerable to the most severe damage when they are forming. If a substance is introduced during a particular structure’s critical period (time of development), the damage to that structure may be greater. For example, the ears and arms reach their critical periods at about 6 weeks after conception. If a mother exposes the embryo to certain substances during this period, the arms and ears may be malformed.
The amount of exposure: Some substances are not harmful unless the amounts reach a certain level. The critical level depends in part on the size and metabolism of the mother. In other words, the dose of a teratogen that a pregnancy is exposed to is a determinant of the effects and that dose can be modified by not only the mother's exposure but by characteristics of the mother.
Genetics: Genetic make-up also plays a role on the impact a particular teratogen might have on the child. Just as genes later in life make us more or less susceptible to various disorders, a child's genes may make it more or less likely to exhibit the effects of exposure to a teratogen. This is suggested by fraternal (dizygotic) twin studies who are exposed to the same prenatal environment, yet do not experience the same teratogenic effects. The genetic make-up of the mother can also have an effect; some mothers may process a teratogen such that its effect on her offspring is minimized - effectively decreasing exposure that occurs.

It should be noted that the effects of teratogens are not something that can be studied experimentally in humans. In other words, as it would be unethical to expose a human embryo or fetus to radiation, alcohol, cocaine, or high doses of caffeine, our understanding of the danger of such things has developed through the use of correlational studies and animal studies.

Chart showing stages of prenatal development, beginning with the dividing zygote and implantation within the first two weeks, then the CNS and heart formation in week 3, then eyes, the heart, limbs, and ears between weeks 3 and 8, then genitals and increase brain development after week 9. — Figure $\PageIndex{6}$ : Critical Periods of Prenatal Development. (Unknown; Not Specified via Lumen Learning)

The Germinal Period

The Embryonic Period

The Fetal Period

Environmental Risks

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