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14.8: References

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Feb 28, 2025
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- 14.7: Key Terms
- 14.9: Multiple Choice

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14.1 Basic Principles of Pharmacology

DeWire, S. M., Yamashita, D. S., Rominger, D. H., Liu, G., Cowan, C. L., Graczyk, T. M., Chen, X. T., Pitis, P. M., Gotchev, D., Yuan, C., Koblish, M., Lark, M. W., & Violin, J. D. (2013). A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine. The Journal of Pharmacology and Experimental Therapeutics, 344(3), 708–717. https://doi.org/10.1124/jpet.112.201616

14.2 Psychotherapeutics

Bitsko, R. H., Claussen, A. H., Lichstein, J., et al. (2022). Mental health surveillance among children — United States, 2013–2019. MMWR Supplements, 71(Suppl-2), 1–42.

Boldrini, M., Underwood, M. D., Hen, R., Rosoklija, G. B., Dwork, A. J., John Mann, J., & Arango, V. (2009). Antidepressants increase neural progenitor cells in the human hippocampus. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 34(11), 2376–2389. https://doi.org/10.1038/npp.2009.75

Boldrini, M., Santiago, A. N., Hen, R., Dwork, A. J., Rosoklija, G. B., Tamir, H., Arango, V., & John Mann, J. (2013). Hippocampal granule neuron number and dentate gyrus volume in antidepressant-treated and untreated major depression. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 38(6), 1068–1077. https://doi.org/10.1038/npp.2013.5

Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., ... & Poulton, R. (2003). Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science, 301(5631), 386–389.

Daly, E. J., Trivedi, M. H., Janik, A., Li, H., Zhang, Y., Li, X., Lane, R., Lim, P., Duca, A. R., Hough, D., Thase, M. E., Zajecka, J., Winokur, A., Divacka, I., Fagiolini, A., Cubala, W. J., Bitter, I., Blier, P., Shelton, R. C., Molero, P., … Singh, J. B. (2019). Efficacy of esketamine nasal spray plus oral antidepressant treatment for relapse prevention in patients with treatment-resistant depression: A randomized clinical trial. JAMA Psychiatry, 76(9), 893–903. doi.org/10.1001/jamapsychiatry.2019.1189

David, D. J., Samuels, B. A., Rainer, Q., Wang, J. W., Marsteller, D., Mendez, I., Drew, M., Craig, D. A., Guiard, B. P., Guilloux, J. P., Artymyshyn, R. P., Gardier, A. M., Gerald, C., Antonijevic, I. A., Leonardo, E. D., & Hen, R. (2009). Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression. Neuron, 62(4), 479–493. https://doi.org/10.1016/j.neuron.2009.04.017

Gardner, D. M., Baldessarini, R. J., & Waraich, P. (2005). Modern antipsychotic drugs: a critical overview. CMAJ: Canadian Medical Association Journal = Journal de l'Association Médicale Canadienne, 172(13), 1703–1711. doi.org/10.1503/cmaj.1041064

Genro, J. P., Kieling, C., Rohde, L. A., & Hutz, M. H. (2010). Attention-deficit/hyperactivity disorder and the dopaminergic hypotheses. Expert Review of Neurotherapeutics, 10(4), 587–601. doi.org/10.1586/ern.10.17

Ginsberg, Y., Quintero, J., Anand, E., Casillas, M., & Upadhyaya, H. P. (2014). Underdiagnosis of attention-deficit/hyperactivity disorder in adult patients: a review of the literature. The Primary Care Companion for CNS Disorders, 16(3), PCC.13r01600. https://doi.org/10.4088/PCC.13r01600

Griffiths, R. R., Johnson, M. W., Carducci, M. A., Umbricht, A., Richards, W. A., Richards, B. D., Cosimano, M. P., & Klinedinst, M. A. (2016). Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial. Journal of Psychopharmacology (Oxford, England), 30(12), 1181–1197. doi.org/10.1177/0269881116675513

Harvard Medical School. (2007). National Comorbidity Survey (NCS). Retrieved from https://www.hcp.med.harvard.edu/ncs/index.php. Data Table 1: Lifetime prevalence DSM-IV/WMH-CIDI disorders by sex and cohort.

Löw, K., Crestani, F., Keist, R., Benke, D., Brünig, I., Benson, J. A., Fritschy, J. M., Rülicke, T., Bluethmann, H., Möhler, H., & Rudolph, U. (2000). Molecular and neuronal substrate for the selective attenuation of anxiety. Science (New York, N.Y.), 290(5489), 131–134. doi.org/10.1126/science.290.5489.131

Mayberg, H. S., Silva, J. A., Brannan, S. K., Tekell, J. L., Mahurin, R. K., McGinnis, S., & Jerabek, P. A. (2002). The functional neuroanatomy of the placebo effect. The American Journal of Psychiatry, 159(5), 728–737. https://doi.org/10.1176/appi.ajp.159.5.728

McGrath, J., Saha, S., Chant, D., & Welham, J. (2008). Schizophrenia: a concise overview of incidence, prevalence, and mortality. Epidemiologic Reviews, 30, 67–76. doi.org/10.1093/epirev/mxn001

Miyamoto, S., Duncan, G. E., Marx, C. E., & Lieberman, J. A. (2005). Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs. Molecular Psychiatry, 10(1), 79–104. https://doi.org/10.1038/sj.mp.4001556

Moncrieff, J., Cooper, R. E., Stockmann, T., Amendola, S., Hengartner, M. P., & Horowitz, M. A. (2023). The serotonin theory of depression: a systematic umbrella review of the evidence. Molecular Psychiatry, 28(8), 3243–3256. https://doi.org/10.1038/s41380-022-01661-0

Moreno, F. A., Gelenberg, A. J., Heninger, G. R., Potter, R. L., McKnight, K. M., Allen, J., Phillips, A. P., & Delgado, P. L. (1999). Tryptophan depletion and depressive vulnerability. Biological Psychiatry, 46(4), 498–505. https://doi.org/10.1016/s0006-3223(99)00095-5

Moreno, F. A., Heninger, G. R., McGahuey, C. A., & Delgado, P. L. (2000). Tryptophan depletion and risk of depression relapse: a prospective study of tryptophan depletion as a potential predictor of depressive episodes. Biological Psychiatry, 48(4), 327–329. https://doi.org/10.1016/s0006-3223(00)00893-3

Murrough, J. W., Iosifescu, D. V., Chang, L. C., Al Jurdi, R. K., Green, C. E., Perez, A. M., Iqbal, S., Pillemer, S., Foulkes, A., Shah, A., Charney, D. S., & Mathew, S. J. (2013). Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial. The American Journal of Psychiatry, 170(10), 1134–1142. https://doi.org/10.1176/appi.ajp.2013.13030392

Pierre, J. M. (2005). Extrapyramidal symptoms with atypical antipsychotics: incidence, prevention and management. Drug Safety, 28(3), 191–208. https://doi.org/10.2165/00002018-200528030-00002

Ringeisen, H., Edlund, M. J., Guyer, H., Geiger, P., Stambaugh, L. F., Dever, J. A., Liao, D., Carr, C. M., Peytchev, A., Reed, W., McDaniel, K., & Smith, T. K. (2023). Mental and substance use disorders prevalence study: Findings report. RTI International.

Ross, S., Bossis, A., Guss, J., Agin-Liebes, G., Malone, T., Cohen, B., Mennenga, S. E., Belser, A., Kalliontzi, K., Babb, J., Su, Z., Corby, P., & Schmidt, B. L. (2016). Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial. Journal of Psychopharmacology (Oxford, England), 30(12), 1165–1180. doi.org/10.1177/0269881116675512

Substance Abuse and Mental Health Services Administration (SAMHSA), Center for Behavioral Health Statistics and Quality. (2020). National Survey on Drug Use and Health 2022. Retrieved from https://datafiles.samhsa.gov/

Tornese, P., Sala, N., Bonini, D., Bonifacino, T., La Via, L., Milanese, M., Treccani, G., Seguini, M., Ieraci, A., Mingardi, J., Nyengaard, J. R., Calza, S., Bonanno, G., Wegener, G., Barbon, A., Popoli, M., & Musazzi, L. (2019). Chronic mild stress induces anhedonic behavior and changes in glutamate release, BDNF trafficking and dendrite morphology only in stress vulnerable rats. The rapid restorative action of ketamine. Neurobiology of Stress, 10, 100160. https://doi.org/10.1016/j.ynstr.2019.100160

Vargas, M. V., Dunlap, L. E., Dong, C., Carter, S. J., Tombari, R. J., Jami, S. A., Cameron, L. P., Patel, S. D., Hennessey, J. J., Saeger, H. N., McCorvy, J. D., Gray, J. A., Tian, L., & Olson, D. E. (2023). Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors. Science (New York, N.Y.), 379(6633), 700–706. doi.org/10.1126/science.adf0435

Wang, J. W., David, D. J., Monckton, J. E., Battaglia, F., & Hen, R. (2008). Chronic fluoxetine stimulates maturation and synaptic plasticity of adu .2008" rel="freelink" title="https://doi.org/10.1523/JNEUROSCI.3632-07.2008">https://doi.org/10.1523/JNEUROSCI.3632-07.2008

14.3 Neural Circuitry of Drug Reward

Berridge, K. C., Venier, I. L., & Robinson, T. E. (1989). Taste reactivity analysis of 6-hydroxydopamine-induced aphagia: Implications for arousal and anhedonia hypotheses of dopamine function. Behavioral Neuroscience, 103(1), 36–45. doi.org/10.1037//0735-7044.103.1.36

Berridge, K. C. (2012). From prediction error to incentive salience: Mesolimbic computation of reward motivation. The European Journal of Neuroscience, 35(7), 1124–1143. doi.org/10.1111/j.1460-9568.2012.07990.x

Di Chiara, G., & Imperato, A. (1988). Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proceedings of the National Academy of Sciences of the United States of America, 85(14), 5274–5278. doi.org/10.1073/pnas.85.14.5274

Kalivas, P. W., & O'Brien, C. (2008). Drug addiction as a pathology of staged neuroplasticity. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 33(1), 166–180. https://doi.org/10.1038/sj.npp.1301564

Substance Abuse and Mental Health Services Administration (SAMHSA), Center for Behavioral Health Statistics and Quality. (2023). National Survey on Drug Use and Health 2021. Retrieved from https://datafiles.samhsa.gov/

Schultz, W. (1986). Responses of midbrain dopamine neurons to behavioral trigger stimuli in the monkey. Journal of Neurophysiology, 56(5), 1439–1461. doi.org/10.1152/jn.1986.56.5.1439

Schultz, W., Apicella, P., Scarnati, E., & Ljungberg, T. (1992). Neuronal activity in monkey ventral striatum related to the expectation of reward. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 12(12), 4595–4610. https://doi.org/10.1523/JNEUROSCI.12-12-04595.1992

Schultz, W., Apicella, P., & Ljungberg, T. (1993). Responses of monkey dopamine neurons to reward and conditioned stimuli during successive steps of learning a delayed response task. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 13(3), 900–913. https://doi.org/10.1523/JNEUROSCI.13-03-00900.1993

Volkow, N. D., Wang, G. J., Fowler, J. S., Logan, J., Gatley, S. J., Wong, C., Hitzemann, R., & Pappas, N. R. (1999). Reinforcing effects of psychostimulants in humans are associated with increases in brain dopamine and occupancy of D(2) receptors. The Journal of Pharmacology and Experimental Therapeutics, 291(1), 409–415.

Whiting, P. F., Wolff, R. F., Deshpande, S., Di Nisio, M., Duffy, S., Hernandez, A. V., Keurentjes, J. C., Lang, S., Misso, K., Ryder, S., Schmidlkofer, S., Westwood, M., & Kleijnen, J. (2015). Cannabinoids for medical use: A systematic review and meta-analysis. JAMA, 313(24), 2456–2473. doi.org/10.1001/jama.2015.6358

Wise, R. A. (1980). The dopamine synapse and the notion of ‘pleasure centers’ in the brain. Trends in Neurosciences, 3(4), 91–95.

14.4 Neurobiology of Addiction

Bolla, K. I., Eldreth, D. A., London, E. D., Kiehl, K. A., Mouratidis, M., Contoreggi, C., Matochik, J. A., Kurian, V., Cadet, J. L., Kimes, A. S., Funderburk, F. R., & Ernst, M. (2003). Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a decision-making task. NeuroImage, 19(3), 1085–1094. https://doi.org/10.1016/s1053-8119(03)00113-7

Bond, C., LaForge, K. S., Tian, M., Melia, D., Zhang, S., Borg, L., Gong, J., Schluger, J., Strong, J. A., Leal, S. M., Tischfield, J. A., Kreek, M. J., & Yu, L. (1998). Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: Possible implications for opiate addiction. Proceedings of the National Academy of Sciences of the United States of America, 95(16), 9608–9613. doi.org/10.1073/pnas.95.16.9608

DiNieri, J. A., Wang, X., Szutorisz, H., Spano, S. M., Kaur, J., Casaccia, P., Dow-Edwards, D., & Hurd, Y. L. (2011). Maternal cannabis use alters ventral striatal dopamine D2 gene regulation in the offspring. Biological Psychiatry, 70(8), 763–769. https://doi.org/10.1016/j.biopsych.2011.06.027

Ehrman, R., Ternes, J., O'Brien, C. P., & McLellan, A. T. (1992). Conditioned tolerance in human opiate addicts. Psychopharmacology, 108(1-2), 218–224. https://doi.org/10.1007/BF02245311

Ersche, K. D., Turton, A. J., Pradhan, S., Bullmore, E. T., & Robbins, T. W. (2010). Drug addiction endophenotypes: Impulsive versus sensation-seeking personality traits. Biological Psychiatry, 68(8), 770–773. https://doi.org/10.1016/j.biopsych.2010.06.015

Koob, G. F. (2008). A role for brain stress systems in addiction. Neuron, 59(1), 11–34. https://doi.org/10.1016/j.neuron.2008.06.012

Martinez, D., Broft, A., Foltin, R. W., Slifstein, M., Hwang, D. R., Huang, Y., Perez, A., Frankle, W. G., Cooper, T., Kleber, H. D., Fischman, M. W., & Laruelle, M. (2004). Cocaine dependence and D2 receptor availability in the functional subdivisions of the striatum: Relationship with cocaine-seeking behavior. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 29(6), 1190–1202. https://doi.org/10.1038/sj.npp.1300420

Moustafa, A. A., Parkes, D., Fitzgerald, L., Underhill, D., Garami, J., Levy-Gigi, E., ... & Misiak, B. (2021). The relationship between childhood trauma, early-life stress, and alcohol and drug use, abuse, and addiction: An integrative review. Current Psychology, 40, 579–584.

Siegel, S. (1999). Drug anticipation and drug addiction. The 1998 H. David Archibald Lecture. Addiction (Abingdon, England), 94(8), 1113–1124. doi.org/10.1046/j.1360-0443.1999.94811132.x

Volkow, N. D., Wang, G. J., Fowler, J. S., Logan, J., Gatley, S. J., Hitzemann, R., Chen, A. D., Dewey, S. L., & Pappas, N. (1997). Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects. Nature, 386(6627), 830–833. https://doi.org/10.1038/386830a0

Volkow, N. D., Fowler, J. S., & Wang, G. J. (2004). The addicted human brain viewed in the light of imaging studies: Brain circuits and treatment strategies. Neuropharmacology, 47 Suppl 1, 3–13. https://doi.org/10.1016/j.neuropharm.2004.07.019

Wise, R. A., & Koob, G. F. (2014). The development and maintenance of drug addiction. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 39(2), 254–262. https://doi.org/10.1038/npp.2013.261

14.1 Basic Principles of Pharmacology

14.2 Psychotherapeutics

14.3 Neural Circuitry of Drug Reward

14.4 Neurobiology of Addiction

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